Is Postoperative Radiotherapy Beneficial in the Management of Stage I‐II Squamous‐Cell Carcinoma of the Uterine Cervix with Negative Metastatic Nodes and Positive Parametrial Involvement?: A Retrospective Review of 70 Patients
Identifieur interne : 00CF07 ( Main/Exploration ); précédent : 00CF06; suivant : 00CF08Is Postoperative Radiotherapy Beneficial in the Management of Stage I‐II Squamous‐Cell Carcinoma of the Uterine Cervix with Negative Metastatic Nodes and Positive Parametrial Involvement?: A Retrospective Review of 70 Patients
Auteurs : Akio Takamura [Japon] ; Jun-Etsu Mizoe [Japon] ; Takuro Arimoto [Japon] ; Tadashi Kamada [Japon] ; Hiroki Shirato [Japon] ; Yoshisuke Matsuoka [Japon] ; Masayoshi Tomita [Japon] ; Goro Irie [Japon]Source :
- Asia‐Oceania Journal of Obstetrics and Gynaecology [ 0389-2328 ] ; 1993-06.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique (), Carcinome épidermoïde (), Carcinome épidermoïde (radiothérapie), Femelle, Humains, Invasion tumorale, Métastase lymphatique, Période postopératoire, Récidive tumorale locale, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus (), Tumeurs du col de l'utérus (radiothérapie), Études rétrospectives.
- MESH :
- radiothérapie : Carcinome épidermoïde, Tumeurs du col de l'utérus.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Carcinome épidermoïde, Femelle, Humains, Invasion tumorale, Métastase lymphatique, Période postopératoire, Récidive tumorale locale, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Combined Modality Therapy (contraindications), Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Postoperative Period, Retrospective Studies, Survival Rate, Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery).
- MESH :
- contraindications : Combined Modality Therapy.
- radiotherapy : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- surgery : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Aged, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Postoperative Period, Retrospective Studies, Survival Rate.
Abstract
Seventy patients having squamous‐cell carcinoma of the uterine cervix FIGO Stage I‐II with negative lymph nodes and positive parametrial involvement received postoperative radiotherapy following radical hysterectomy and pelvic lymphadenectomy. In 48 patients with microscopic parametrial invasion, the 5‐year survival rate was 92%. The other 22 patients with macroscopic parametrial involvement had a 5‐year survival rate of 75%. The overall recurrence rate was 13% (9 of 70). The sites of failure were 3 pelvic alone, 5 distant metastases alone, and 1 combined pelvis and para‐aortic lymph node. All of those with recurrence were Stage‐II cases. The absolute pelvic‐control rate was 94.3% (66/70). Fifty‐six percent of the patients experienced mild‐to‐moderate lymphedema. Severe complications requiring surgical intervention were observed in 6 patients (5 bowel obstructions and 1 femoral head fracture). A review of the literature suggests that early carcinoma can be successfully treated by surgery alone. Taking into consideration the risk and benefits involved, postoperative radiotherapy is not recommended for most cases with cervical carcinoma with negative lymph nodes and positive parametrial involvement in the present form, despite excellent local control. However, no definite conclusion can be drawn from this retrospective analysis.
Url:
DOI: 10.1111/j.1447-0756.1993.tb00365.x
Affiliations:
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of Radiology, Asahikawa Kosei Hospital, 1–24 Asahikawa, Hokkaido 078</wicri:regionArea><wicri:noRegion>Hokkaido 078</wicri:noRegion></affiliation></author><author><name sortKey="Mizoe, Jun Tsu" sort="Mizoe, Jun Tsu" uniqKey="Mizoe J" first="Jun-Etsu" last="Mizoe">Jun-Etsu Mizoe</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Radiation Health, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Arimoto, Takuro" sort="Arimoto, Takuro" uniqKey="Arimoto T" first="Takuro" last="Arimoto">Takuro Arimoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Hokkaido University School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Kamada, Tadashi" sort="Kamada, Tadashi" uniqKey="Kamada T" first="Tadashi" 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AND GYNAECOLOGY</title><idno type="ISSN">0389-2328</idno><idno type="eISSN">1447-0756</idno><imprint><biblScope unit="vol">19</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="151">151</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1993-06">1993-06</date></imprint><idno type="ISSN">0389-2328</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0389-2328</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (surgery)</term><term>Combined Modality Therapy (contraindications)</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Neoplasm Recurrence, Local</term><term>Postoperative Period</term><term>Retrospective Studies</term><term>Survival Rate</term><term>Uterine Cervical Neoplasms (radiotherapy)</term><term>Uterine Cervical Neoplasms (surgery)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique ()</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Femelle</term><term>Humains</term><term>Invasion tumorale</term><term>Métastase lymphatique</term><term>Période postopératoire</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus ()</term><term>Tumeurs du col de l'utérus (radiothérapie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="contraindications" xml:lang="en"><term>Combined Modality Therapy</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Invasiveness</term><term>Neoplasm Recurrence, Local</term><term>Postoperative Period</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Carcinome épidermoïde</term><term>Femelle</term><term>Humains</term><term>Invasion tumorale</term><term>Métastase lymphatique</term><term>Période postopératoire</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seventy patients having squamous‐cell carcinoma of the uterine cervix FIGO Stage I‐II with negative lymph nodes and positive parametrial involvement received postoperative radiotherapy following radical hysterectomy and pelvic lymphadenectomy. In 48 patients with microscopic parametrial invasion, the 5‐year survival rate was 92%. The other 22 patients with macroscopic parametrial involvement had a 5‐year survival rate of 75%. The overall recurrence rate was 13% (9 of 70). The sites of failure were 3 pelvic alone, 5 distant metastases alone, and 1 combined pelvis and para‐aortic lymph node. All of those with recurrence were Stage‐II cases. The absolute pelvic‐control rate was 94.3% (66/70). Fifty‐six percent of the patients experienced mild‐to‐moderate lymphedema. Severe complications requiring surgical intervention were observed in 6 patients (5 bowel obstructions and 1 femoral head fracture). A review of the literature suggests that early carcinoma can be successfully treated by surgery alone. Taking into consideration the risk and benefits involved, postoperative radiotherapy is not recommended for most cases with cervical carcinoma with negative lymph nodes and positive parametrial involvement in the present form, despite excellent local control. However, no definite conclusion can be drawn from this retrospective analysis.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Takamura, Akio" sort="Takamura, Akio" uniqKey="Takamura A" first="Akio" last="Takamura">Akio Takamura</name></noRegion><name sortKey="Arimoto, Takuro" sort="Arimoto, Takuro" uniqKey="Arimoto T" first="Takuro" last="Arimoto">Takuro Arimoto</name><name sortKey="Irie, Goro" sort="Irie, Goro" uniqKey="Irie G" first="Goro" last="Irie">Goro Irie</name><name sortKey="Kamada, Tadashi" sort="Kamada, Tadashi" uniqKey="Kamada T" first="Tadashi" last="Kamada">Tadashi Kamada</name><name sortKey="Matsuoka, Yoshisuke" sort="Matsuoka, Yoshisuke" uniqKey="Matsuoka Y" first="Yoshisuke" last="Matsuoka">Yoshisuke Matsuoka</name><name sortKey="Mizoe, Jun Tsu" sort="Mizoe, Jun Tsu" uniqKey="Mizoe J" first="Jun-Etsu" last="Mizoe">Jun-Etsu Mizoe</name><name sortKey="Shirato, Hiroki" sort="Shirato, Hiroki" uniqKey="Shirato H" first="Hiroki" last="Shirato">Hiroki Shirato</name><name sortKey="Takamura, Akio" sort="Takamura, Akio" uniqKey="Takamura A" first="Akio" last="Takamura">Akio Takamura</name><name sortKey="Tomita, Masayoshi" sort="Tomita, Masayoshi" uniqKey="Tomita M" first="Masayoshi" last="Tomita">Masayoshi Tomita</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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